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It is also indicated for OCD [1] (obsessive-compulsive disorder), panic disorder, bulimia nervosa and prementstrual dysphoric disorder Prozac and Zoloft are powerful prescription medications used to treat depression and other issues. About fluoxetine Prozac (fluoxetine) is a depression pill used to treat a wide range of psychological disorders but it is mainly used to treat major depression in adults and children. Both medications can reduce anxiety, fear, and compulsive behaviors There are different kinds of medicine for depression. Doctors don't fully understand what causes the so-called "poop-out" effect or antidepressant. Take Lexapro once a day, with or without a meal, morning or evening, as directed by your doctor The antidepressant drug Prozac. : Abilify (aripiprazole)– an antipsychotic medication used in combination with an antidepressant Adapin. The generic version of Prozac is fluoxetine, while the generic version of Zoloft is sertraline hydrochloride. 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